|
Malignant histiocytosis (also known as "Histiocytic medullary reticulosis") is a rare hereditary disease found in the Bernese Mountain Dog and humans, characterized by histiocytic infiltration of the lungs and lymph nodes. The liver, spleen, and central nervous system can also be affected. Histiocytes are a component of the immune system that proliferate abnormally in this disease. In addition to its importance in veterinary medicine, the condition is also important in human pathology.〔(Malignant histiocytoses. DermNet NZ )〕 ==Histiocytic disorders== A histiocyte is a differentiated tissue cell that has its origin in the bone marrow. The source for histiocytes is the monocyte/macrophage line. Monocytes (found in the blood) and macrophages (found in tissue) are responsible for phagocytosis (ingestion) of foreign material in the body. Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and presenting them to T cells. They arise from monocytes. Histiocytic disorders refer to diseases that are caused by abnormal behavior of these cells. They include the following: *Reactive diseases of Langerhans cells (most important feature in immune histochemistry is expression of E-cadherin) * *Histiocytomas *Reactive histiocytosis (immunohistochemical features show that interstitial/dermal DCs are involved) * *Cutaneous histiocytosis (CH) * *Systemic histiocytosis (SH) *Reactive diseases of macrophages * *Hemophagocytic syndrome - a condition where macrophages phagocytose myeloid and erythroid precursors (similar to hemophagocytic lymphohistiocytosis in humans) *Histiocytic sarcoma complex (immunohistochemical features of dendritic cells, possibly interdigitating or perivascular DCs) * *Malignant histiocytosis * *Diffuse histiocytic sarcoma * *Localized histiocytic sarcoma *Malignant diseases of macrophages * *Histiocytic lymphoma 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Malignant histiocytosis」の詳細全文を読む スポンサード リンク
|